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KMID : 1044520170800040392
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Tuberculosis and Respiratory Diseases
2017 Volume.80 No. 4 p.392 ~ p.400
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Incidence and Risk Factors of Pneumonia in Hospitalized Patients with Seasonal Influenza A or B
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Chu Seong-Jun
Park Sang-Joon
Koo So-My
Kim Yang-Ki
Kim Ki-Up
Uh Soo-Taek
Kim Tae-Hyung
Park Su-Yeon
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Abstract
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Background: Most patients with influenza recover spontaneously or following treatment with an anti-viral agent, but some patients experience pneumonia requiring hospitalization. We conducted a retrospective review to determine the incidence and risk factors of pneumonia in hospitalized patients with influenza A or B.
Methods: A total of 213 patients aged 18 years or older and hospitalized with influenza between January 2012 and January 2015 were included in this study. A reverse-transcriptase polymerase chain reaction assay was used to detect the influenza A or B virus in the patients' sputum samples. We collected demographic and laboratory data, combined coexisting diseases, and radiologic findings.
Results: The incidence of pneumonia was higher in patients in the influenza A group compared to those in the influenza B group (68.6% vs. 56.9%), but this difference was not statistically significant. The presence of underlying respiratory disease was significantly associated with pneumonia in the influenza A group (adjusted odds ratio [OR], 3.975; 95% confidence interval [CI], 1.312?12.043; p=0.015). In the influenza B group, the white blood cell count (adjusted OR, 1.413; 95% CI, 1.053?1.896; p=0.021), platelet count (adjusted OR, 0.988; 95% CI, 0.978?0.999; p=0.027), and existence of an underlying medical disease (adjusted OR, 15.858; 95% CI, 1.757?143.088; p=0.014) were all significantly associated with pneumonia in multivariate analyses.
Conclusion: The incidence of pneumonia was 65.7% in hospitalized patients with influenza A or B. The risk factors of pneumonia differed in hospitalized patients with influenza A or B.
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KEYWORD
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Pneumonia, Influenza, Risk Factors, Comorbidity
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